In 1799, Edward Jenner, a licensed physician, wrote An Inquiry into the Causes and Effects of the Variolae Vaccinae, a Disease Discovered in some of the Western Counties of England, Particularly Gloucestershire, and Known by the Name of the Cow Pox. A second edition was published in 1800, which Osler bought. The book is not very hefty or large, having an approximate weight of 5 lbs and an approximate size of 22 by 27cm. The cover is paper with a red pattern of swirls covering cardboard and does not have the book’s title, unlike most books today. The spine is made of leather and the corners…